Download Drug Delivery Nanoparticles Formulation and Characterization by Yashwant Pathak, Deepak Thassu PDF

By Yashwant Pathak, Deepak Thassu

Nanoparticles, items of nanotechnology, are of accelerating curiosity to the pharmaceutical neighborhood. they could raise drug solubility, increase bioavailability, enable tissue concentrating on, provide lowered side-effects, and increase healing efficacy. offering the main pertinent and useful matters within the production and organic software of nanoparticles, this resource provides state of the art clinical contributions by means of pro specialists within the box.

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The smaller particles showed a 27-fold higher transfection than the larger nanoparticles in COS-7 cell line and a fourfold higher transfection in HEK-293 cell line. CONCLUSIONS Nanoparticles offer unique properties as compared to microor macroparticles. Salient features include the following:       Small size. High surface area. Easy to suspend in liquids. Deep access to cells and organelles. Variable optical and magnetic properties. 22-mm filter. Drugs, being mostly organic compounds, are more sticky in nature as compared to inorganic materials, such as silica or metal oxides.

Dedrick RL, Bischoff KB. Pharmacokinetics in applications of the artificial kidney. Chem Eng Progr Symp Ser 1968; 64:32–44. 12. Mapleson WW. An electric analogue for uptake and exchange of inert gases and other agents. J Appl Physiol 1963; 18: 197–204. 13. Jani P, Halbert GW, Langridge J, Florence AT. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and Fundamentals of Drug Nanoparticles 19 particle size dependency. J Pharm Pharmacol 1990; 42(suppl 12): 821–826. 14. Jani P, Halbert GW, Langridge J, Florence AT.

Precipitation from Solution or Building-Up Process In this process, a drug is dissolved in a solvent to achieve molecular solution. Then, the nanoparticle precipitate is obtained either by removing the solvent rapidly or by mixing an antisolvent (nonsolvent) to the solution, reducing its solubilizing strength. Initially, nuclei are formed, which grow because of condensation and coagulation giving the final particles. If the rate of desolubilization is slow, then sticky nuclei/ particles are formed that have a higher tendency of agglomeration, giving large-size final particles.

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