Download Clinical Ocular Pharmacology by Jimmy D. Bartlett (Eds.) PDF
By Jimmy D. Bartlett (Eds.)
This variation goals to supply functional, clinically invaluable info in ocular pharmacology in response to presently authorised medical ideas and criteria of perform. nearly each medical point of drug utilization in fundamental eye care is roofed. New details is given on ocular pharmacokinetics and techniques for supplying medicines to the attention, B-blockers, new drug dosage types, ocular steroids and anti-flammatory medicinal drugs and lots more and plenty extra
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Jpn J Ophthalmol 1980; 24:251-259. 10. Hind HW, Goyan FM. A new concept of the role of hy drogen ion concentration and buffer system in the prepa ration of ophthalmic solution. J Am Pharm Assoc 1947; 36:33-41. 11. Holly FJ. Formation and stability of the tear film. Int Ophthalmol Clin 1973;13:73-96. 12. Holly FJ. Tear film formation and rupture. In: Holly FJ, ed. The precorneal tear film. Dry Eye Institute, 1986. 13. Mishima S, Maurice DM. Oily layer of tear film and evap oration from corneal surface.
1 The pivalyl groups are removed by esterases in the cornea, leaving epinephrine to act at the receptor site. 5 Systemic ab sorption of the drug is thereby greatly reduced. This drug has achieved wide acceptance for the treatment of glaucoma since its introduction. A prodrug that by virtue of lipophilicity can cross the blood-vitreous barrier into the vitreous humor might then be metabolized into a drug that has a greater ionic charge and that therefore cannot recross the barrier readily. An anti-inflammatory drug or antibiotic of low systemic toxicity could thus be introduced by the sys temic route into the eye at relatively infrequent inter vals, becoming trapped by metabolic alteration, then supplying the aqueous and corneal tissues with a nearzero-order supply of drug over a prolonged period.
48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. transparency. Biochemistry of the eye, Symp. Tutzing Cas tle, August 1966; 51-61. Davson H. Physiology of the eye. New York: Academic Press, 1980. Johnston MC, Noden DM, Hazelton RD, et al. Origins of avian ocular and periocular tissues. Exp Eye Res 1979;29:2743. Maurice DM. The cornea and sclera. In: Davson H, ed. The eye. New York: Academic Press, 1984;lb. Hodson S, Miller F. The bicarbonate ion pump in the endothelium which regulates the hydration of rabbit cornea.