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By Richard V. Heinzelman

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P. Deniker, P. Peron-Magnan, C. Eliet-Le Guillou and M. Hanus, Therapie, 2lg (1971). 48. L. Lemberger, E. Sernatinger and R. Kuntzman, Biochem. 02l (1970). 49. V. G. Yashunskii, V. 2. Gorkh, M. D. Mashkovskii, A. A. Altshuler, I. V. Veryovkha and L. E. Kholodov, J. Med. , 1013 (1971). 2, 2, 2, 2, 5, 2, 2, 2, 2, 2, 2, 2, 2, 2, 164, 2, El 2, Chap. 2 Antidepressives, Stimulants 50. R. A. Altshuler and B. I. -Fam. , 51. D. Wheatley, B r i t . J. , 117, 573 (1970). 4, 29 Kaiser, Zirkle 59 (1971). 52.

N. Dhawan, Arch. Int. , E,3x) (1970). 46. H. M. van Praag, J. Korf and F. van Woudenberg, Psychophannacologia, l8, 412 (1970). 47. P. Deniker, P. Peron-Magnan, C. Eliet-Le Guillou and M. Hanus, Therapie, 2lg (1971). 48. L. Lemberger, E. Sernatinger and R. Kuntzman, Biochem. 02l (1970). 49. V. G. Yashunskii, V. 2. Gorkh, M. D. Mashkovskii, A. A. Altshuler, I. V. Veryovkha and L. E. Kholodov, J. Med. , 1013 (1971). 2, 2, 2, 2, 5, 2, 2, 2, 2, 2, 2, 2, 2, 2, 164, 2, El 2, Chap. 2 Antidepressives, Stimulants 50.

Rubidium i o n seems t o have opposite effects from l i t h i u m i o n on CA metabolism and it has been suggested t h a t i t may have c l i n i c a l antidepressive a c t i v i t y . ' Although t h e r o l e s o f NE and 5-HT i n t h e antidepressive a c t i o n o f the t r i c y c l i c s have n o t been e s t a b l i s h e d , t h e r e i s l i t t l e doubt b u t t h a t the stimulatory a c t i o n of amphetamine i s t o a l a r g e e x t e n t mediated through CA pathways. Early experiments emphasized effects of t h e drug on NA systems.

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